TRIM16

TRIM16
Identifiers
Aliases	TRIM16, EBBP, tripartite motif containing 16
External IDs	OMIM: 609505; MGI: 2137356; HomoloGene: 4726; GeneCards: TRIM16; OMA:TRIM16 - orthologs
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	62,741,634 bp
Gene ontology
Molecular function	DNA binding; zinc ion binding; interleukin-1 binding; protein binding; metal ion binding; NACHT domain binding; transferase activity;
Cellular component	cytoplasm; PML body; intracellular anatomical structure; cytosol; plasma membrane;
Biological process	histone H4 acetylation; positive regulation of keratinocyte differentiation; positive regulation of transcription, DNA-templated; response to organophosphorus; positive regulation of retinoic acid receptor signaling pathway; response to retinoic acid; histone H3 acetylation; response to growth hormone;
	Sources:Amigo / QuickGO
Orthologs
	10626
	94092
	ENSG00000221926
	ENSMUSG00000047821
	O95361
	Q99PP9
	NM_006470
	NM_053169
NP_006461; NP_001335049; NP_001335050; NP_001335051; NP_001335053;
	NP_001335054; NP_001335055; NP_001335048
	NP_444399
	Wikidata
View/Edit Human	View/Edit Mouse

Tripartite motif-containing protein 16 is a protein that in humans is encoded by the TRIM16 gene.^[4]^[5]

This gene was identified as an estrogen and anti-estrogen regulated gene in epithelial cells stably expressing estrogen receptor. The protein encoded by this gene contains two B box domains and a coiled-coiled region that are characteristic of the B box zinc finger protein family.

The proteins of this family have been reported to be involved in a variety of biological processes including cell growth, differentiation and pathogenesis. Expression of this gene was detected in most tissues. Its function, however, has not yet been determined.^[5]

References

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000047821 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.
^ ^a ^b "Entrez Gene: TRIM16 tripartite motif-containing 16".

Liu HL, Golder-Novoselsky E, Seto MH, et al. (1999). "The novel estrogen-responsive B-box protein (EBBP) gene is tamoxifen-regulated in cells expressing an estrogen receptor DNA-binding domain mutant". Mol. Endocrinol. 12 (11): 1733–48. doi:10.1210/mend.12.11.0193. PMID 9817599.
Beer HD, Munding C, Dubois N, et al. (2002). "The estrogen-responsive B box protein: a novel regulator of keratinocyte differentiation". J. Biol. Chem. 277 (23): 20740–9. doi:10.1074/jbc.M111233200. hdl:20.500.11850/91604. PMID 11919186.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Munding C, Keller M, Niklaus G, et al. (2006). "The estrogen-responsive B box protein: a novel enhancer of interleukin-1beta secretion". Cell Death Differ. 13 (11): 1938–49. doi:10.1038/sj.cdd.4401896. PMID 16575408. S2CID 8953820.
Cheung BB, Bell J, Raif A, et al. (2006). "The estrogen-responsive B box protein is a novel regulator of the retinoid signal". J. Biol. Chem. 281 (26): 18246–56. doi:10.1074/jbc.M600879200. PMID 16636064.

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[refGRCm38Ensembl-1] GRCm38: Ensembl release 89: ENSMUSG00000047821 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11331580-4] Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L, Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci S, Pelicci PG, Ballabio A (May 2001). "The tripartite motif family identifies cell compartments". EMBO J. 20 (9): 2140–51. doi:10.1093/emboj/20.9.2140. PMC 125245. PMID 11331580.

[entrez-5] "Entrez Gene: TRIM16 tripartite motif-containing 16".

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References

Further reading